Cannabidiol cbd, a nonpsychoactive component of cannabis sativa, has been shown by us, to have an antiinflammatory effect in collageninduced arthritis in dba mice and in type 1 diabetes in nod mice. Psammomys obesus israeli sand rat is a gerbil that is a unique animal model of the metabolic syndrome. Psammomys obesus fat sand rat, psammomys vexillaris thin sand rat species references. Background and aimsa major impediment to establishing new treatments for nonalcoholic steatohepatitis is the lack of suitable animal models that accurately mimic the biochemical and metabolic characteristics of the disease. As inflammation is a process involved in diabetes type 2, we administered cbd to psammomys obesus sand rats, a species which develops diabetes type 2 when fed high. Increased susceptibility of islets from diabetesprone. Fat sand rat psammomys obesus longevity, ageing, and life. Spontaneous hepatomas and hepatic preneoplastic changes were observed in sand rats psammomys obesus from two colonies.
Generally four stages of consecutive progression to dia. In its native environment, psmammomys obesus gerbil is healthy, with a metabolicendocrine system that is adjusted to desert life with a low caloric diet composed of halophilic plant staple. In this study, superparamagnetic ferrite nanoparticles doped with zinc, exhibiting highly enhanced saturation. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. Jul 05, 2017 genome sequence of a diabetesprone rodent. The fat sand rat psammomys obesus is a terrestrial mammal from the gerbil subfamily that is mostly found in north africa and the middle east, ranging from mauritania to the arabian peninsula. The terrarium has a drawer underneath where they can build a tunnel system. However, on a high energetic diet, psammomys obesus is predisposed to develop rapidly diabetes and obesity, mainly due to the feedback inhibition of the insulin signaling pathway. The desert gerbil psammomys obesus as a model for metformin. The sand rat psammomys obesus as an experimental animal in. Behavior of psammomys obesus in the algerian sahara 299 along the saoura, oases occur at intervals of several km, and support tamarix trees, cultivated date palms, and small gardens. Psammomys obesus sand rat is a wellestablished model of type2 diabetes and obesity, which shares most metabolic parameters of the human metabolic syndrome.
There are two recognised species of psammomys, these being p. Cell dysfunction in psammomys obesus, an animal with type 2 diabetes, diabetes, 2001, pp. The complete nuclear dna genome of one psamomys species, p. Dose response of vildagliptin, dppiv activity and glp1 levels. Genetic studies in psammomys obesus walder, ken, segal, david, jowett, jeremy, blangero, john, zimmet, paul and collier, greg 2003, genetic studies in psammomys. All animals were handled in accordance to the regulations specified under the protection of animals act by the authority in denmark, european union and novo nordisk as. The fat sand rat psammomys obesus is the main reservoir host of cutaneous leishmaniasis in north africa and western asia. The architecture of the desert rodent psammomys obesus has been studied by means of standard histologic procedures and by single nephron injections. Oct 12, 20 my two fat sand rats in their new terrarium. Psammomys is a genus of rodent in the muridae family. We have evaluated and correlated the histopathology, metabolic and functional renal alterations occurring in the diabetic psammomys. Pdf tapeworm identification in the fat sand rat psammomys. A major impediment to establishing new treatments for nonalcoholic steatohepatitis is the.
This species usually lives in sandy deserts, but may also be found in rocky terrain or saline marsh areas. Groups of 5 animals were inoculated with doses of 1010 7 parasites via each route of inoculation. The aim of this study was to explore a unique polygenic animal model of metabolic disease as a model of nonalcoholic steatohepatitis by determining the effects of. Patients with noninsulindependent diabetes niddm show an increase in the relative plasma levels of proinsulin and proinsulin conversion intermedia. In order to understand better the transmission of this disease to humans, a longitudinal study of a population of the rodent was carried out in tunisia. The vascular organization of the kidney of psammomys obesus has been studied by injecting silicone rubber into the renal arterial and venous vessels and by standard histological techniques. Pdf psammomys obesus, a particularly important animal model. One group of animals was kept on lowenergy diet and seven groups were given highenergy diet hed that. Islet protection and amelioration of diabetes type 2 in. The etymology of the genus name derives from the two ancient greek words psammos, meaning sand, and mus, meaning mouse, rat. Psammomys obesus, the sand rat, is a saharan species which exhibits a different feeding specialization, eating the leaves and stems of succulent, salty.
A male psammomys obesus was obtained from hadassah medical school, israel. The sand rat psammomys obesus constitutes a model to study seasonal changes and several metabolic disorders. Psammomys obesus, a particularly important animal model. Male hebrew university psammomys obesus gerbils were studied. Ginklasipika han iucn an species komo diri gud kababarakan. Files are available under licenses specified on their description page. Novel genes in the liver of diabetic psammomys obesus core. Read spatial distribution of psammomys obesus rodentia, gerbillinae in relation to vegetation in the negev desert of israel, mammalia international journal of the systematics, biology and ecology of mammals on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
The sand rat, psammomys obesus, develops type 2 diabetic. The most effective way to counter cardiovascular complications is early diagnosis and the safest noninvasive diagnostic approach is magnetic resonance imaging mri. Met prevents the progression of insulin resistance in diabetesprone p. The susceptibility of psammomys obesus sand rat and meriones tristrami tristrams jird to neospora caninum was investigated by subcutaneous s. Impact of glucotoxicity induced in vivo and in vitro in. Role of insulin and the igf system in renal hypertrophy in. Apr 01, 2002 the susceptibility of psammomys obesus sand rat and meriones tristrami tristrams jird to neospora caninum was investigated by subcutaneous s. The mean body weight for the colony at 16 weeks of age was 198. In order to investigate the effect and mechanism of liraglutide and vildagliptin in diabetic psammomys obesus, we examined proliferation and apoptosis of. Protein tyrosine phosphatase activity in insulinresistant rodent psammomys obesus article pdf available in international journal of experimental diabetes research 33.
Figure 1 shows a frequency histogram for the bodyweightvariable in a total of 633 animals. Pdf the psammomys obesus lives in natural desert habitat on low energy le diet. Our study is conducted on an experimental model of gerbillid class psammomys obesus, gopher, a deserti colous rodent from the. An psammomys obesus in nahilalakip ha genus nga psammomys, ngan familia nga muridae. A major impediment to establishing new treatments for nonalcoholic steatohepatitis is the lack of suitable animal models that accurately mimic the biochemical and metabolic characteristics of the disease. Reproduction and abundance of the fat sand rat psammomys.
Gerbillinae, a diurnal gerbillid rodent, is herbivorous and able to thrive while consuming only the saltbush atriplex. An wikimedia commons mayda media nga nahahanungod han. Rapid development of nonalcoholic steatohepatitis in. Fat sand rats are very selective in their diet, only eating stems and leaves of plants from the. Both colonies originated from 10 sand rats captured in the judean desert in 1969. This file contains additional information such as exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. An wikispecies in mayada impormasyon nga may pagkahisumpay ha. The cortex is composed of 4 to 5 layers of glomeruli, which lie closely put together, the glomeruli often. Male psammomys obesus were kept on a high energy diet during the experiments. Supplementary information appendix materials and methods. Full text full text is available as a scanned copy of the original print version. Psammomys species psammomys obesus common name fat sand rat synonyms psammomys algiricus, psammomys roudairei, psammomys tripolitanus, psammomys obesus dianae, psammomys obesus nicolli, psammomys obesus terraesanctae lifespan, ageing, and relevant traits maximum longevity 3.
The occurrence of increased plasma insulin levels and of hyperglycem. Pdf psammomys obesus, a particularly important animal. Despite hyperglycemia, insulin mrna levels initially remained unchanged and then decreased gradually to 15% of the basal level by 3 weeks. Purpose diabetic retinopathy dr is a leading cause of blindness, yet pertinent animal models are uncommon. Myocardial structural and biological anomalies induced by. Cardiovascular diseases are the most prevalent cause of morbidity and mortality affecting millions of people globally. Role of insulin and the igf system in renal hypertrophy in diabetic psammomys obesus sand rat. Morphometry and immunohistochemistry of follicles growth and. Cretzschmar first described psammomys obesus in detail in 1828 from specimens he observed in alexandria, egypt. When they are fed a highenergy he diet, they develop diabetes. Sequencing of the complete nuclear dna genome of psammomys obesus. All but 2 of the sand rats inoculated with doses of 10.
There are two entries to the drawer under the two caves. Mammal species of the world a taxonomic and geographic reference. Whereas the cortical vasculature is not principally different from that of other species, the medullary vessels show some unique features in the psammomys. Psammomys in mammal species of the world at bucknell.
Our study is conducted on an experimental model of gerbillid class psammomys obesus, gopher, a deserti colous rodent from the region of beniabbes, south west. In order to perform breeding laboratory conditions, the reproductive function of this species living in north occidental algerian sahara was studied. At the age of 6 months, and increasing in multiplicity. Pdf protein tyrosine phosphatase activity in insulin. This page was last edited on 6 december 2014, at 05. Links to pubmed are also available for selected references. The histogenesis of hepatoma occurring spontaneously in a. However, when housed under laboratory conditions and fed a standard rodent diet 20% kcalfat, a proportion of p.
The vascular organization of the kidney of psammomys obesus. The animals were maintained in an animal research facility and the experiments performed according to the regulations of the hadassah university committee on animal care and use. Get a printable copy pdf file of the complete article 4. Psammomys obesus, a model of dietresponsive type 2 diabetes, shows markedly depleted insulin stores when given a highenergy he diet. The diabetic animals present a 54% increase in gfr after one month of. This file is licensed under the creative commons attributionshare alike 4. All structured data from the file and property namespaces is available under the creative commons cc0 license. Energy requirements of fat sand rats psammomys obesus and their. The sand rat psammomys obesus is a gerbil species native to deserts of north africa and the middle east, and is constrained in its ecology because.
The psammomys obesus lives in natural desert habitat on low energy le diet, however when maintained in laboratory conditions with high energy he diet it exhibits pathological metabolic changes resembling those of type 2 diabetes. Role of insulin and the igf system in renal hypertrophy in diabetic psammomys obesus sand rat, nephrology dialysis transplantation, 2003, pp. Animals were maintained in a closed barrier and housed in solid bottom polypropylene cages equipped with water bottles and white pine woodchip bedding and were fed a standard artificial diet. The fat sand rat psammomys obesus is a terrestrial mammal from the gerbil subfamily that is. The structural organization of the kidney of the desert. Wildscreen s arkive project was launched in 2003 and grew to become the worlds biggest encyclopaedia of life on earth. Desert sand rats psammomys obesus are indigenous to middle eastern semiarid regions in which their diet consists of succulent. Liraglutide, but not vildagliptin, restores normoglycaemia. With the help of over 7,000 of the worlds best wildlife filmmakers and photographers, conservationists and scientists, arkive.
The fat sand rat psammomys obesus obesus undergoes agere. As other rodent kidneys rat, mouse, the psammomys kidney consists of two types of nephrons, 66% short looped and 34% long looped nephrons. Psammomys obesus sand rat, a new animal model of non. An psammomys obesus in uska species han rodentia nga ginhulagway ni philipp jakob cretzschmar hadton 1828. If you do not see its contents the file may be temporarily unavailable at the journal website or you do not have a pdf plugin installed and enabled in your browser. The sand rat has some unique attributes, which make it a valuable experimental animal.